All You Need To Know About Inflammatory Bowel Disease


The prime culprit behind inflammatory bowel disease, an incurable disorder that causes abdominal pain, weight loss and diarrhoea, has been identified by the researchers. According to what has been reported in the journal Cell Reports, this discovery can also reveal a pathway to treatment. The studies imply that disrupting the function of the gene RNF5 could help in treating the disease. So, what is inflammatory bowel disease and its causes. Let' find out in this article.

Inflammatory bowel disease (IBD) is a term that represents two intestinal disorders - ulcerative colitis and Crohn's disease. These conditions cause prolonged inflammation of the digestive tract.

The digestive tract comprises of the stomach, small intestine, large intestine, mouth, and oesophagus. All of these organs are responsible for breaking down food, removing the waste products and absorbing the nutrients. If inflammation occurs anywhere in the digestive tract, it disrupts the function of these organs which can be painful and life-threatening.

Ulcerative colitis affects the large intestine (colon) and Crohn's disease affects the digestive system starting from the mouth to the anus. Another condition called microscopic colitis affects the colon and rectum, leading to inflammation in these organs.


The exact cause is unknown. However, genes and problems with the immune system have been associated with IBD.

Depending on the severity of inflammation, the symptoms of inflammatory bowel disease may vary. The symptoms include:

Your doctor will first ask about your family history and your bowel movements followed by some tests which include the following:

According to the Centers for Disease Control and Prevention (CDC), at first anti-inflammatory drugs like aminosalicylates, corticosteroids and immunomodulators are used to treat IBD. Patients are also required to take several vaccinations to prevent further infections. Severe cases of inflammatory bowel disease require surgery where the damaged portions of the digestive tract are removed.

IBD can't be prevented. However, you could reduce the risk of developing IBD by consuming healthy foods, exercising regularly and quitting smoking.


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